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Nitrogenous bases covalently linked to a sugar with and without phosphate groups; used for synthesis, cell signaling, and as cofactors in enzymatic reactions; includes pyrimidine, purine, pyridine, flavin, pyrrolopyrimidine, and triazole varieties.
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Guanosine is an aromatic organic molecule and a purine nucleoside. It is present in the cerebrospinal fluid intestinal cells blood-brain barrier and in brain microvessels.
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Adenosine is a purine nucleoside base which is the precursor of adenosine triphosphate or ATP and is utilized thoroughly throughout the entire body in general metabolism. Extracellular adenosine acts as a local modulator with a generally cytoprotective function in the body. Its effects on tissue protection and repair fall into four categories increasing the ratio of oxygen supply to demand protecting against ischaemic damage by cell conditioning triggering anti-inflammatory responses and the promotion of angiogenesis.
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2 -Deoxyadenosine 5 -monophosphate disodium a nucleic acid AMP derivative is a deoxyribonucleotide found in DNA 2 -Deoxyadenosine 5 -monophosphate disodium can be used to study adenosine-based interactions during DNA synthesis and DNA damage[1]
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2 -O-Methyl-ATP is a chemically modified derivative of ATP in which the hydroxyl group at the ribose 2 position is replaced with a methyl group This ribose modification confers resistance to nuclease-mediated degradation thereby increasing its biological stability The modified nucleotide is commonly employed in biomedical research to investigate RNA structure-function relationships and RNA modification pathways and to study interactions influencing RNA polymerase specificity and catalytic activity Additionally 2 -O-Methyl-ATP serves as a tool in probe design for RNA interference experiments and aids in elucidating intracellular metabolic pathways involving nucleotide analogs
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ATP-polyamine-biotin is a cell-permeable ATP analogue used as an efficient kinase co-substrate to transfer a biotin tag to kinase substrates in vitro and in live cells. It facilitates detection and enrichment of phosphorylated proteins for downstream analysis in biochemical and cell-based assays.
Promotes biotin labeling of kinase substrates in live cells.
Functions as an efficient ATP cosubstrate for kinases.
Enables detection and enrichment of phosphorylated proteins.
Provided with high purity suitable for biochemical assays.
Available in multiple pack sizes, including 10 mg.
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2'-Deoxyuridine is a brain-penetrant pyrimidine nucleotide associated with nervous system diseases. It can increase chromosome breakage and reduce thymidylate synthetase activity. This compound serves as a precursor in the synthesis of Edoxudine and is an analogue of 5-ethynyl-2'-deoxyuridine. It has demonstrated the ability to lessen microglial activation and enhance oxidative stress damage by modulating glycolytic metabolism in brain injury models, indicating its potential for Alzheimer's disease research.
Brain-penetrant pyrimidine nucleotide.
Associated with nervous system diseases.
Can increase chromosome breakage.
Reduces thymidylate synthetase activity.
Precursor in synthesis.
Analogue of other compounds.
Reduces microglial activation.
Improves oxidative stress damage.
Modulates glycolytic metabolism in brain injury.
Promising for Alzheimer's disease research.
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2'-Deoxycytidine, a deoxyribonucleoside, can inhibit the biological effects of Bromodeoxyuridine (Brdu). It is essential for the synthesis of nucleic acids and can be used for cancer research.
Deoxyribonucleoside
Inhibits biological effects of bromodeoxyuridine (Brdu)
Essential for the synthesis of nucleic acids
Can be used for cancer research
Inhibits tumor growth in mice
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Adenosine-5 -triphosphate (ATP) is an important molecule in vivo for energy storage and metabolism and is often called the molecular unit of currency of intracellular energy transfer ATP is a coenzyme in multiple reactions as well as a substrate for multiple kinases where it helps to propagate a signal either inside or outside of the cell
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